Protein Phosphatase 2C

One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.

Also Known As:

Magnesium-Dependent Protein Phosphatase 2C beta; PP2C beta; PP2Cepsilon; PP2Cgamma; PPM1 Magnesium-Dependent Protein Phosphatases; PPM1 Protein Phosphatases; PPM1D Phosphatase; PPM1E Phosphatase; PPM1G Phosphatase; Ppm1b Phosphatase; Protein Phosphatase 1D Magnesium-Dependent, delta isoform; Protein Phosphatase 2C beta; Protein Phosphatase 2C delta; Protein Phosphatase 2C epsilon; Protein Phosphatase 2C gamma; Ptc2 Phosphatase; 2C, Protein Phosphatase; Magnesium Dependent Protein Phosphatase 2C beta; PPM1 Magnesium Dependent Protein Phosphatases; Phosphatase 2C, Protein; Phosphatase, PPM1D; Phosphatase, PPM1E; Phosphatase, PPM1G; Phosphatase, Ppm1b; Phosphatase, Ptc2; Phosphatases, PPM1 Protein; Protein Phosphatase 1D Magnesium Dependent, delta isoform; Protein Phosphatases, PPM1; beta, PP2C

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Phosphoprotein Phosphatases: 1211
        Protein Phosphatase 2C: 37
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Phosphoprotein Phosphatases: 1211
      - Protein Phosphatase 2C: 37

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